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Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. 4! I hope this information helps Luke and any others its relevant too. [5] It is on the World Health Organization's List of Essential Medicines. Graded amounts of extracellular ATP (eATP) are released from cells in proportion to stress. Ive currently run out of it but once I source a good organic variety somewhere, Im going to infuse it and make up a batch of tea to store in the fridge can then drink it anytime without having to go through the process of making it. [11], The molecular formula of suramin is C51H40N6O23S6. This tea helps with vascular and heart diseases. Thank you! The synthesis of suramin was an extension of Paul Ehrlich's pioneering work that showed that certain chemical dyes were concentrated in microbial parasites like the trypanosomes that cause African . "Suramin" is the antidote to the bioweapons and transmission. Lots of amazing eating benefits in those ones. (2020). Create an account to follow your favorite communities and start taking part in conversations. anyone with more of a brain than me have any ideas? Have you been tested for this virus? This is a deplorable fact, and a very scary one. 3 (1985): 265-273. Suramin and trypan blue were detected using scheduled multiple reaction monitoring (MRM) with a dwell time of 30 ms in negative mode and retention time window of 7.5-8.5 min for suramin and 8.4 . [2], It is unknown whether it is safe for the baby when a woman takes it while breastfeeding. Dr. Naviaux frequently says, Our work is not about suramin, or any other single drug. 20. "Antiproliferative effects of suramin on lymphoid cells. Medical Disclaimer: I am no longer a practicing medical professional, and I am not doctor. I haven't seen night awake or silly giggling in the middle of the night since he started Kudzu. Jacques Update:Facebook and social media platforms are cracking down on Conservative/holistic health content. She discusses suramin and pine needles, corruption surrounding that, and gives many more suggestions: !function(r,u,m,b,l,e){r._Rumble=b,r[b]||(r[b]=function(){(r[b]._=r[b]._||[]).push(arguments);if(r[b]._.length==1){l=u.createElement(m),e=u.getElementsByTagName(m)[0],l.async=1,l.src="https://rumble.com/embedJS/u4"+(arguments[1].video?'. , But I know that people have sprayed round up around their yards on dandelions and thistles. Hosang, Markus. They are SO strict with raw over here. The precise molecular basis of this inhibitory effect is still unknown. Myers, Charles, Michael Cooper, Cy Stein, Renato LaRocca, M. M. Walther, Gary Weiss, Peter Choyke, Nancy Dawson, Seth Steinberg, and Margaret M. Uhrich. However, despite increased lipid solubility, alcohols with a molecular volume of > or = 46.1 ml/mol (1-butanol, 1-pentanol, trichloroethanol, and dichloroethanol) were without effect on the ATP-activated current. This has me very excited. Clinical trial evidence of suramin and autism. [2] Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur. The exceptions to this are the P2Y12 inhibitors like Plavix, which inhibit ADP-stimulated platelet aggregation. The simplest and most common of weeds are often the very medicine we need to counteract our ill health. are there any meds that might be good alternatives to suramin? Careful clinical trials will be needed over several years at several sites to learn how to use low-dose suramin safely in autism, and to identify drugdrug interactions and rare side effects that cannot currently be predicted. As we know, oil and water do not mix, but this mixes the oil into the water long enough for me to have a drink. "Antimicrobial activity of the essential oil of young pine shoots (Picea abies L.). Suramin Definition. I'm fascinated and excited by this new research on cell danger response (CDR): Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial abstract and the ramifications for autism as well as anxiety and other chronic health conditions. Clinically, suramin works by removing negative signals that block or slow natural child development. 6. Suramin is manmade and is not a natural product found anywhere in Nature. Boom-chakalaka, phreaks! Therefore only 5 boys received suramin by infusion. "Suramin inhibition of growth factor receptor binding and mitogenicity in AKR2B cells. Could you please attach links if possible. I have never actually taken turpentine it makes me think of the turps used to wash out paint brushes and makes me gag at the thought but I have watched a BioChemist share how to make your own and how to take it. They were ahead of their time back then. JavaScript is disabled. I did feel better with better health after I drank it myself. The N/W/O and all their minions. Virol J 13, 149 (2016). Still, I do drink it occasionally. I will continue to research it, but at this time Im not convinced. Suramin contains six aromatic systems four benzene rings, sandwiched by a pair of naphthalene moieties plus four amide functional groups (in addition to the urea) and six sulfonic acid groups. Further development of suramin was passed from Dr. Naviauxs university research lab to the private sector. Hi Luke, 24 (2020): 8331-8347. [8][9] It is considered first-line treatment for Trypanosoma brucei rhodesiense, and second-line treatment for early-stage Trypanosoma brucei gambiense, where pentamidine is recommended as first line. Journal of Clinical Oncology 7, no. Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. She was annoyed people were being told to make it. Pine Needle Tea. [10] Other rare side effects include symptoms of liver dysfunction such as tenderness in upper abdomen, jaundice in eyes and skin, unusual bleeding or bruising. Quercetin. Suramin may cause severe hypersensitivity reactions (shock and loss of consciousness). And I get the best of both worlds. 1! 3 (2006): 899-906, 18.https://pubchem.ncbi.nlm.nih.gov/compound/Suramin-sodium. 10. We have two sons with Autism and are verbal but are not using full sentences accompanied by the usual jumping, head and hand movements and jumping. ", 10.Kartnig, Theodor, Franz Still, and Franz Reinthaler. As an easily accessible and low-cost natural source, they are 3! B: May be acceptable. "Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer." Naviaux Lab, 2023. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Some batches of suramin contain impurities that are brown in color. [10] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision. When I had an organic yard full of dandelion flowers I would harvest the flowers every morning, saut them and cook them into my scrambled eggs. Though it has been investigated for other diseases, including cancer, it is not approved for any therapeutic use in the United States. Personally, 40mg of Emodin a day for the past three weeks has not produced great results. Pine Trees are widely available throughout the world and make an amazing tea high in vitamin C and A. Coffey Jr, Robert J., Edward B. Leof, Gary D. Shipley, and Harold L. Moses. Maca Root 8050mg Per Caps, 4 Months' Supply Supports Reproductive Health Natural. Theres an antidote, because these people wouldnt be injecting people unless they knew the answer. http://www.fedup.com.au, Dr Judy explicitly says that pine needle tea will NOT act as anecdote, in fact, it can be toxic and has similar properties to terpentine. 1 (1987): 143-148. 2 (1991): 155-157. Also, I have written quite a bit about this type of thing in https://marilynjwilliams.com check out the top menu. About 500-1000 mg of fish oil per day is recommended for children dealing with ADHD. Suramin is manmade and is not a natural product found anywhere in Nature. Nos gustara mantener en contacto! Thank you Lizzy for sharing this with us so much appreciated. The respective distribution of glycosome volumes and for cells treated for 72 h with suramin is shown as a bar graph. Find many great new & used options and get the best deals for PINE NEEDLE TEA 70GM PINUS SILVESTRIS VITAMIN A C ANTIVIRAL ANTIOXIDANT SURAMIN at the best online prices at eBay! ", 19. COVID-19 pandemic. Ivermectin is a medication widely used in low- and middle-income . Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Albulescu, I.C., Kovacikova, K., Tas, A., Snijder, E.J., and van Hemert, M.J. (2017). Before you begin treatment with this medicine . I do you a concern about the med beds and whether the DNA is actually being reconstructed our is it possible that our DNA is being changed-much the way the jab is changed and damaged. Our health will be so improved it will be wonderful. These are proving to be beneficial for people who have taken the jab, or those who come in contain with injected people and find they are experiencing bad symptoms. It is still early to say but maybe this will enter the top three interventions. However, it is imperative to choose the right pine needles as there are 20 known toxic varieties of pine trees. It is a growth factor antagonist for palliative treatment in hormone-refractory prostate cancer and hormone-responsive metastatic prostate cancer.. Purpose. Now, a new study reviews the potential for curcumin, a natural alkaloid derived from turmeric, and nanosystems to treat COVID-19. It would be interesting to know if I can get raw camel milk in Australia at least in the powdered form. "Antiproliferative effects of suramin on lymphoid cells." Eastern White Pine Tree Needles: A Natural Source of Anti-Infective Compounds, Suramin is strongly inhibitory to the replication of the coronavirus spike protein. "Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19." It is our hope that each success will lay the groundwork for more successes, and soon there will be a drug, device, and therapeutic Renaissance that will create dozens of new tools that doctors can use to regulate the cell danger response and help patients heal. Do you think that Rheum Palmatum is the richest plant? Thankfully, God gave us wisdom in this world! "Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer. I was desperate, and I gave her one capsule, 150mg, of Sytrinol. 2. ! [2], Suramin was made at least as early as 1916. (especially on purinergic signaling.) [16], Suramin was first made by the chemists Oskar Dressel, Richard Kothe and Bernhard Heymann at Bayer AG laboratories in Elberfeld, after research on a series of urea-like compounds. Thats because I buy Fennel essential oil (100% pure, therapeutic grade) and drop a couple of drops into my bottle of water. Jaw dropping information on all food and the bodies response including learning difficulties. Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles. Suramin has no listed mild interactions with other drugs. Food Shortage Coming Soon, County Returns $1.2M NIH Funds & Confirms Vaxx is a Bioweapon, Protect Babies Thru Adults From Dioxin Toxicity w/ Adequate Vit C, DETOX Dioxin Air & Soil Exposure w/ Broccoli Sprouts For Pennies, Natures Penicillin: For Pneumonia, Earache, Flu, Bronchitis & More. In summary, a lowered pHe enhanced the activity of all agonists at P2X2 receptors but, with the exception of suramin, not antagonists. Journal of ethnopharmacology 35, no. Unfortunately, the lawns that do not have any yellow flowers have often been treated with RoundUp which is about the very worst thing you can do. I do seek scientific confirmation of the safety and effectiveness of the herbs and remedies I use. I was reading just yesterday about the Douglas Fir pine tree. [15], The mechanism of action for suramin is unclear, but it is thought that parasites are able to selectively uptake suramin via receptor-mediated endocytosis of drug that is bound to low-density lipoproteins and, to a lesser extent, other serum proteins. As her life is hounded by the authorities, Im guessing maybe she has had to back-peddle for the sake of her life. But, I would research it to the uttermost if I were you! Funny how uridine is a p2y2 agonist and so many people take it as a nootropic. Sartor, Oliver, Catherine A. McLellan, Charles E. Myers, and M. M. Borner. Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle. Korean Journal of Veterinary Research 33, no. If you do purchase one or more, I will receive a small remuneration. Ive just stumbled upon upon your site and discovered suramin can be obtained naturally. Give it a shake and there you have it, another nice bottle of Fennel water! Dont forget to also check what else you need to do to build your immune system strong it will be more than worth it in the end. A few Dandelion leaves in salads are good, and Fennel is great to eat. and turpentine with sugar taken in a very small dose attracts viral loads to the sugar and the turpentine kills the viral load. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143661/, https://news.ycombinator.com/item?id=14458230. Cat's Claw. The research is promising and the findings are backed up by similar studies. Having said that, we can do a lot more about it than simply sitting around and waiting to see who is harmed or dies. Are there any supplements or lifestyle factors we can utilize to emulate the effects that suramin has? This is an extremely important wild edible to know- as. The most effective dosage solution is the Pine Needle Tincture. Quercetin is an antioxidant found naturally in . The active ingredients in wormwood are toxic to most types of intestinal worms, including Giardia lamblia, a parasite responsible for giardiasis. For research, treatments, and personal stories regarding Chronic Fatigue Syndrome (CFS)/Myalgic Encephalomyelitis (ME). Dr. Naviaux no longer has any control over the next clinical studies or the priorities of different diseases for testing, although he is recommending ASD, ME/CFS, post-acute SARS-CoV-2 multi-system chronic fatigue syndrome, also called long-COVID, and post-treatment Lyme disease (PTLDS) as a few of the top candidates. Regarding our own experiment with natural antipurinergic therapy, we've been trialing Kudzu for the past three weeks and the outcome has been pretty impressive. He also talks about some other VERY interesting information that you have to hear for yourself And of course, a health disclaimer. 5. This recent study was double-blind, placebo-controlled and involved 10 boys, ages 5 to 14 years, [] You wouldnt just pour anything down the spout of your car and expect it to keep on going, would you? Choose what fits your situation best. Suramin is, after all, derived from pine needle oil. Nothing I say on this blog is intended to treat or prevent disease. It is a symmetric molecule in the center of which lies a urea (NHCONH) functional group. I am not a total fan of the taste but absolutely love the aroma of it before the water hits it. It prevents the association of heteromeric G proteins and therefore the receptors guanine exchange functionality (GEF). In addition, pharmaceutical grade suramin is hard to make. Many dont want to allow their bubble to burst as they feel so safe and secure tucked away inside there. We administered suramin, an anti-parasitic drug and reverse transcriptase inhibitor, to 15 patients with metastatic cancer. You can even make DRAH your browser homepage. If you continue to use this site we will assume that you are happy with it. Ive seen some dandelions in a vegetable patch that were so big I could hardly believe how big they were. Naviaux, et al. Oxymatrine is an immunomodulator that Dr Chia uses to treat enterovirus-associated ME/CFS. Disclaimer: The information presented in this article and podcast are for informational purposes only. There was some discussion on Phoenix rising about alternatives but it all got a bit confusing for me. [24][25][26][27], 8,8'-{Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}di(1,3,5-naphthalenetrisulfonic acid), O=C(Nc1cc(ccc1C)C(=O)Nc3c2c(cc(cc2c(cc3)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c8cccc(NC(=O)Nc7cc(C(=O)Nc6cc(C(=O)Nc5c4c(cc(cc4c(cc5)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)ccc6C)ccc7)c8, InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80), The references used may be made clearer with a different or consistent style of, World Health Organization's List of Essential Medicines, Learn how and when to remove this template message, "Suramin Injection Advanced Patient Information", "Micromedex Detailed Drug Information for the Consumer: Suramin (Injection route)", "Our Formulary Infectious Diseases Laboratories CDC", "Trypanosomiasis, human African (sleeping sickness)", "CDC Infectious Diseases Laboratory: Our Formulary", "Suramin Injection Advanced Patient Information - Drugs.com", "Synthesis and StructureActivity Relationships of Suramin-Derived P2Y, "Inhibition of receptor/G protein coupling by suramin analogues", "International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy", "International union of pharmacology. One important way that stress-triggered eATP is released occurs through pannexin 1 containing channels in the cell membrane. Specifically, cat's claw works to supercharge your immune system, while simultaneously repairing damaged DNA and boosting your virus-fighting white blood cells ( 14 ). There are so many wonderful natural medicines in the world. This practical guide on natural alternatives has more than 200 supporting studies that represent the best of science-backed strategies for nutritional interventions in the prevention and treatment of COVID-19. I have been taking Sytrinol, 150 mg x 2 daily, for well over 6 months. Proceedings of the National Academy of Sciences 83, no. NAC (N-acetyl cysteine) accelerates detoxification and is . You can obtain enough from pine needle tea (pine, spruce, cedar and fir) . cryoEM studies reveal the binding of suramin to the RdRp catalytic site to prevent . This medicine works by causing the parasites to lose energy, which causes their death. Suramin may cause serious side effects. "Suramin in the treatment of AIDS: mechanism of action." Receive this printable PDF: 31 Days of Praying Scripture for Newlyweds.. Before going, I would want to ascertain she knows about this and could help you with the right dosage. C: Use with caution if benefits outweigh risks. THE CONTENT ON THIS SITE IS PRESENTED IN SUMMARY FORM, IS GENERAL IN NATURE, AND IS PROVIDED FOR INFORMATIONAL PURPOSES ONLY; IT IS NOT ADVICE, NOR SHOULD IT BE TREATED AS SUCH. Press J to jump to the feed. Each of the 19 different purinergic receptors have different functions, and new roles for specific P2Y, P2X and P1 receptors are still being discovered. A vitamin B complex contains B6, B12, biotin, and folate, essential vitamins for the nervous system and can help with the formation of serotonin. You can alsofind me onInstagram,Truth Social(a new free-speech conservative channel), MeWe andTelegram. The information on this website has not been evaluated by the FDA and is not intended to diagnose, treat, prevent, or cure any disease. For a better experience, please enable JavaScript in your browser before proceeding. The synthesis of suramin was an extension of Paul Ehrlichs pioneering work that showed that certain chemical dyes were concentrated in microbial parasites like the trypanosomes that cause African sleeping sickness. This information isn't meant to treat, cure or prevent any disease. It has a sweet taste and I like it. 16.Spigelman, Zachary, Amy Dowers, Susan Kennedy, Dennis DiSorbo, Michael O'Brien, Ronald Barr, and Ronald McCaffrey. [2], The most frequent adverse reactions are nausea, vomiting, diarrhea, abdominal pain, and a feeling of general discomfort. Ive used it many times, but it is so true. "Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin." (137) $15.99 New. How long would it take. An in silico drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both representing attractive therapeutic targets for many chronic inflammatory conditions. Our bodies are built in such a way they can withstand being treated badly for a time, but it doesnt go on forever. Consult your own doctor. S U R A M I N Suramin. Now new drugs need to be made and studied individually that are selective for just one or two of the 19 purinergic receptors. [1][2] It is the treatment of choice for sleeping sickness without central nervous system involvement. National Center for Biotechnology Information. "Studies on antitumor effects of pine needles, Pinus densiflora Sieb. 11.Croci, R., Pezzullo, M., Tarantino, D., Milani, M., Tsay, S.-C., Sureshbabu, R., Tsai, Y.-J., Mastrangelo, E., Rohayem, J., Bolognesi, M., et al. Betsholtz, Christer, Ann Johnsson, Carl-Henrik Heldin, and Bengt Westermark. I have bought this before for myself just for good health. Curcumin was the active ingredient in an intravenous infusion that killed the patient of a California-licensed naturopathic doctor. Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. Common side effects include nausea, vomiting, diarrhea, headache, skin tingling, and weakness. The natural alternative of Suramin - and the original compound is found in Eastern White Pine (pinus strobus) needles. [4], Suramin causes a fair number of side effects. 15.Mooon, Jeong-jo, Young-bok Han, and Jin-suk Kim. Gourley, P.L. It seems promising! Of-course its going to react. 14.Stein, C. A., R. V. LaRocca, R. Thomas, N. McAtee, and Charles E. Myers. (5) $11.00 New. Suramin is not extensively metabolized and about 80% is eliminated via the kidneys. [10] Suramin can also cause loss of appetite and irritability. Suramin is a medication used to treat African sleeping sickness and river blindness. Just a point of clarification. Ethanol was found to decrease the time-constant of deactivation of ATP-gated ion channels without affecting the time-constant of activation, indicating that ethanol inhibits the function of these receptors by an allosteric decrease in the affinity of the agonist binding site. When he had an ME attack (as he called them), he would boil a load of soya beans, which he claimed made him feel much better.